STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TM_1005Transcriptional regulator, putative; Similar to GB:L19201 SP:P09377 GB:X06058 PID:305009 PID:42724 percent identity: 57.24; identified by sequence similarity; putative. (299 aa)    
Predicted Functional Partners:
ribBA
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
    
  0.875
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.806
TM_1006
Oxidoreductase, aldo/keto reductase family; Similar to GB:AE000511 PID:2314358 percent identity: 71.74; identified by sequence similarity; putative.
 
     0.735
TM_1004
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 74.81; identified by sequence similarity; putative.
  
    0.558
TM_1164
2-oxoacid ferredoxin oxidoreductase, alpha subunit; Similar to GB:AE000666 percent identity: 68.99; identified by sequence similarity; putative.
     
 0.489
TM_1184
pleD-related protein; Similar to PID:1652841 percent identity: 50.78; identified by sequence similarity; putative.
   
  
 0.447
TM_0656
Conserved hypothetical protein; Similar to SP:P38522 GB:U00096 PID:1742120 PID:1742129 PID:1787557 percent identity: 56.60; identified by sequence similarity; putative.
 
 
 0.444
trpGD
Anthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
     
 0.432
TM_0088
comE protein, putative; Similar to SP:P31772 GB:L42023 PID:1003754 PID:1222365 PID:148874 percent identity: 65.23; identified by sequence similarity; putative; Belongs to the bacterial secretin family.
   
  
 0.411
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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