Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TM_1034UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919 percent identity: 74.59; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (378 aa)    
Predicted Functional Partners:
TM_0583
Lipopolysaccharide biosynthesis protein; Similar to GB:Pyro_h percent identity: 71.97; identified by sequence similarity; putative; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
 
 0.998
glmU
UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.
    
 0.960
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
  
 
  0.957
TM_1033
Mannose-1-phosphate guanylyltransferase; Similar to GB:L11721 SP:P24174 GB:M77127 PID:147164 PID:304878 percent identity: 60.42; identified by sequence similarity; putative.
    
 0.950
wecA
Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.
 
 
 0.909
TM_0862
Glucose-1-phosphate thymidylyltransferase; Similar to PID:1001492 PID:1001590 percent identity: 71.27; identified by sequence similarity; putative.
  
 
 0.889
TM_0644
Hypothetical protein; Identified by sequence similarity; putative.
    
 0.741
TM_0620
Lipopolysaccharide biosynthesis protein; Similar to GP:1276886 percent identity: 50.35; identified by sequence similarity; putative.
  
  
 0.597
TM_0756
Galactosyltransferase-related protein; Similar to GP:2198543 percent identity: 61.83; identified by sequence similarity; putative.
  
  
 0.579
TM_0818
Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.
 
  
 0.511
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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