Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TM_1081Anti-sigma factor antagonist, putative; In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts an anti-sigma factor and thus releases a sigma factor from inhibition; Belongs to the anti-sigma-factor antagonist family. (113 aa)    
Predicted Functional Partners:
TM_0733
sigma-B regulator, putative; Similar to GP:2660754 percent identity: 49.59; identified by sequence similarity; putative.
 
 0.944
TM_1354
Inosine-5-monophosphate dehydrogenase-related protein; Similar to GB:L77117 SP:Q59011 PID:1592337 percent identity: 60.27; identified by sequence similarity; putative.
  
 0.932
TM_0467
Regulatory protein, putative; Similar to PID:1653310 percent identity: 53.02; identified by sequence similarity; putative.
 
 0.881
prmA
Ribosomal protein L11 methyltransferase, putative; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
       0.813
TM_1080
Sugar-phosphate isomerase; Similar to GB:AE000657 percent identity: 77.62; identified by sequence similarity; putative.
       0.813
TM_1364
Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
    0.775
flgH
Flagellar L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
   
    0.775
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.774
TM_1076
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 51.61; identified by sequence similarity; putative.
       0.773
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
       0.773
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.