purB protein (Thermotoga maritima) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

purB

Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative. (431 aa)

Predicted Functional Partners:

purA

0.999

purC

0.999

purH

0.998

purE

0.993

purK

0.991

purD

0.991

purF

0.990

apt

0.990

TM_1251

0.987

adk

0.987

Your Current Organism:

Thermotoga maritima

NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TM_1251	apt	TM_1251	TM_1384	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.568
TM_1251	purA	TM_1251	TM_1096	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.624
TM_1251	purB	TM_1251	TM_1095	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative.	0.987
TM_1251	purC	TM_1251	TM_1243	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:L77117 PID:1592203 percent identity: 68.02; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family.	0.999
TM_1251	purD	TM_1251	TM_1250	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Phosphoribosylamine--glycine ligase; Similar to GB:AE000657 percent identity: 62.47; identified by sequence similarity; putative.	0.999
TM_1251	purE	TM_1251	TM_0446	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.985
TM_1251	purF	TM_1251	TM_1247	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.999
TM_1251	purH	TM_1251	TM_1249	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative.	0.996
TM_1251	purK	TM_1251	TM_0447	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.996
adk	apt	TM_1479	TM_1384	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.975
adk	purA	TM_1479	TM_1096	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.567
adk	purB	TM_1479	TM_1095	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative.	0.987
adk	purH	TM_1479	TM_1249	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative.	0.581
apt	TM_1251	TM_1384	TM_1251	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative.	0.568
apt	adk	TM_1384	TM_1479	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.975
apt	purA	TM_1384	TM_1096	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.830
apt	purB	TM_1384	TM_1095	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative.	0.990
apt	purC	TM_1384	TM_1243	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:L77117 PID:1592203 percent identity: 68.02; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family.	0.418
apt	purD	TM_1384	TM_1250	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylamine--glycine ligase; Similar to GB:AE000657 percent identity: 62.47; identified by sequence similarity; putative.	0.438
apt	purE	TM_1384	TM_0446	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.484

page 1 of 5

Server load: low (36%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About