STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (197 aa)    
Predicted Functional Partners:
tdk
Thymidine kinase; Similar to GB:U00089 SP:P75070 PID:1673767 percent identity: 57.80; identified by sequence similarity; putative.
  
 
 0.997
thyX
Thy1 protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant.
    
 0.996
TM_0118
Ribonucleotide reductase, B12-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.994
TM_0404
Deoxycytidylate deaminase, putative; Similar to GB:AE000782 percent identity: 74.00; identified by sequence similarity; putative.
    
 0.993
TM_1878
UDP-sugar hydrolase; Similar to SP:P07024 PID:757842 GB:U00096 PID:1773162 PID:1786687 percent identity: 62.97; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
  
 
  0.992
surE
Stationary phase survival protein; Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.
    
  0.991
TM_1100
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.78; identified by sequence similarity; putative.
       0.827
TM_1101
Conserved hypothetical protein; Similar to GB:U00096 SP:P76495 PID:1788638 percent identity: 61.35; identified by sequence similarity; putative.
       0.827
purB
Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative.
  
  
 0.820
rnc
Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. Belongs to the ribonuclease III family.
  
  
 0.817
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.