Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (197 aa)    
Predicted Functional Partners:
tdk
Thymidine kinase; Similar to GB:U00089 SP:P75070 PID:1673767 percent identity: 57.80; identified by sequence similarity; putative.
  
 
 0.985
thyX
Thy1 protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant.
    
 0.980
TM_0118
Ribonucleotide reductase, B12-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 
 0.973
TM_0404
Deoxycytidylate deaminase, putative; Similar to GB:AE000782 percent identity: 74.00; identified by sequence similarity; putative.
    
 0.961
TM_1878
UDP-sugar hydrolase; Similar to SP:P07024 PID:757842 GB:U00096 PID:1773162 PID:1786687 percent identity: 62.97; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
   
 
 0.961
surE
Stationary phase survival protein; Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.
    
 0.960
mazG
mazG protein; Catalyzes the hydrolysis of all eight canonical ribonucleoside triphosphates (NTP) and deoxyribonucleoside triphosphates (dNTP) to their corresponding nucleoside monophosphates ((d)NMP) and PPi and subsequently hydrolyzes the resultant PPi to Pi. The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher than corresponding ribonucleoside triphosphates. dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best among the ribonucleoside triphosphates.
    
  0.957
TM_1556
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
  0.957
TM_1100
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.78; identified by sequence similarity; putative.
       0.819
TM_1101
Conserved hypothetical protein; Similar to GB:U00096 SP:P76495 PID:1788638 percent identity: 61.35; identified by sequence similarity; putative.
       0.819
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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