| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TM_1251 | glyA | TM_1251 | TM_0720 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.665 |
| TM_1251 | guaB | TM_1251 | TM_1347 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.698 |
| TM_1251 | purB | TM_1251 | TM_1095 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative. | 0.987 |
| TM_1251 | purC | TM_1251 | TM_1243 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:L77117 PID:1592203 percent identity: 68.02; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. | 0.999 |
| TM_1251 | purD | TM_1251 | TM_1250 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylamine--glycine ligase; Similar to GB:AE000657 percent identity: 62.47; identified by sequence similarity; putative. | 0.999 |
| TM_1251 | purF | TM_1251 | TM_1247 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.999 |
| TM_1251 | purH | TM_1251 | TM_1249 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative. | 0.996 |
| TM_1251 | purL | TM_1251 | TM_1246 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.999 |
| TM_1251 | purN | TM_1251 | TM_1248 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| TM_1251 | purQ | TM_1251 | TM_1245 | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.999 |
| glyA | TM_1251 | TM_0720 | TM_1251 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine cyclo-ligase; Similar to GB:X54199 PID:2425020 PID:2425021 PID:31642 PID:387019 percent identity: 58.48; identified by sequence similarity; putative. | 0.665 |
| glyA | guaB | TM_0720 | TM_1347 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.621 |
| glyA | purB | TM_0720 | TM_1095 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Similar to GB:AE000657 percent identity: 73.60; identified by sequence similarity; putative. | 0.837 |
| glyA | purC | TM_0720 | TM_1243 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:L77117 PID:1592203 percent identity: 68.02; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family. | 0.676 |
| glyA | purD | TM_0720 | TM_1250 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine--glycine ligase; Similar to GB:AE000657 percent identity: 62.47; identified by sequence similarity; putative. | 0.830 |
| glyA | purF | TM_0720 | TM_1247 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.735 |
| glyA | purH | TM_0720 | TM_1249 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative. | 0.993 |
| glyA | purL | TM_0720 | TM_1246 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.675 |
| glyA | purN | TM_0720 | TM_1248 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.985 |
| glyA | purQ | TM_0720 | TM_1245 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.630 |
