STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_1266Hypothetical protein; Identified by sequence similarity; putative. (82 aa)    
Predicted Functional Partners:
TM_1269
Biotin synthetase, putative; Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L- methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster. Belongs to the radical SAM superfamily. HydE family.
 
  
 0.969
TM_1267
thiH protein, putative; Similar to SP:P30140 PID:396329 PID:414236 GB:U00096 PID:1790423 percent identity: 53.87; identified by sequence similarity; putative.
 
     0.938
TM_0079
iron(III) ABC transporter, permease protein; Similar to GB:AE000782 percent identity: 60.69; identified by sequence similarity; putative; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
 0.894
TM_0190
iron(III) ABC transporter, permease protein, putative; Similar to GB:L77117 SP:Q57552 PID:1590869 percent identity: 75.15; identified by sequence similarity; putative; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
 0.894
TM_1268
Hypothetical protein; Identified by sequence similarity; putative.
       0.810
TM_0445
Conserved hypothetical protein; Similar to PID:1001414 PID:1001399 percent identity: 52.55; identified by sequence similarity; putative.
 
     0.795
TM_0080
iron(III) ABC transporter, periplasmic-binding protein, putative; Similar to GB:AL009126 percent identity: 56.83; identified by sequence similarity; putative.
  
 0.770
TM_0189
iron(III) ABC transporter, periplasmic iron-binding protein, putative; Similar to GB:L77117 SP:Q57550 PID:1590868 percent identity: 79.52; identified by sequence similarity; putative.
  
 0.770
aar
Cystathionine gamma-synthase; Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine [...]
       0.630
TM_0417
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 69.78; identified by sequence similarity; putative.
   
  
 0.520
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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