STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aarCystathionine gamma-synthase; Catalyzes the racemization of L-alanine to D-alanine, and of L-glutamate to D-glutamate. The activity is low, but likely physiological since T.maritima lacks canonical alr and murI genes, while D-alanine and D-glutamate are essential components of peptidoglycan. Also displays a more efficient cystathionine beta-lyase (CBL) activity, cleaving cystathionine to homocysteine and pyruvate; however, this reaction seems not to be physiologically relevant since T.maritima possesses an O-acetyl-homoserine thiolase (MetY) that bypasses the need of CBL for methionine [...] (379 aa)    
Predicted Functional Partners:
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.998
TM_0665
Cysteine synthase; Similar to GB:D26185 SP:P37887 PID:467462 GB:AL009126 percent identity: 72.88; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 0.931
TM_0268
5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative.
  
 
 0.921
TM_0270
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 57.03; identified by sequence similarity; putative; Belongs to the methylenetetrahydrofolate reductase family.
  
 0.896
TM_0547
Aspartokinase II; Similar to PID:928811 SP:P53553 percent identity: 67.00; identified by sequence similarity; putative.
  
 
 0.893
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.798
metAA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. Has weak activity with succinyl-CoA as the acyl donor. Belongs to the MetA family.
  
 
 0.778
TM_1269
Biotin synthetase, putative; Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L- methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster. Belongs to the radical SAM superfamily. HydE family.
     
 0.708
TM_0715
tRNA nucleotidyl transferase-related protein; Similar to GB:AE000657 percent identity: 56.71; identified by sequence similarity; putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
 
 0.705
TM_0666
Serine acetyltransferase; Similar to SP:P77985 percent identity: 59.90; identified by sequence similarity; putative.
  
 
 0.660
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.