close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_1359Sensor histidine kinase; Similar to GB:L13078 SP:Q06067 PID:290419 GB:U00096 PID:1736874 percent identity: 56.58; identified by sequence similarity; putative. (755 aa)    
Predicted Functional Partners:
TM_1360
Response regulator; Similar to GB:L09228 SP:P35163 PID:410141 GB:AL009126 percent identity: 65.79; identified by sequence similarity; putative.
 
 
 0.999
fliE
Flagellar hook-basal body complex protein FliE; Similar to GB:M54965 SP:P24502 PID:142917 GB:AL009126 percent identity: 66.67; identified by sequence similarity; putative.
  
 
 0.813
TM_0468
Response regulator; Similar to PID:1575577 GB:AE000512 percent identity: 69.17; identified by sequence similarity; putative.
  
  
 0.809
TM_1362
Motility protein PilT; Similar to GB:AE000657 percent identity: 66.67; identified by sequence similarity; putative.
  
    0.786
TM_1358
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.39; identified by sequence similarity; putative.
       0.785
TM_1655
Response regulator DrrA; Similar to PID:1575577 GB:AE000512 percent identity: 100.00; identified by sequence similarity; putative.
 
  
 0.784
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
       0.774
prfA
Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
       0.739
TM_0842
Response regulator; Similar to PID:1651932 percent identity: 56.68; identified by sequence similarity; putative.
 
 0.736
TM_1704
Hypothetical protein; Identified by sequence similarity; putative.
  
     0.710
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.