Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TM_1360Response regulator; Similar to GB:L09228 SP:P35163 PID:410141 GB:AL009126 percent identity: 65.79; identified by sequence similarity; putative. (116 aa)    
Predicted Functional Partners:
TM_1359
Sensor histidine kinase; Similar to GB:L13078 SP:Q06067 PID:290419 GB:U00096 PID:1736874 percent identity: 56.58; identified by sequence similarity; putative.
 
 
 0.996
TM_1654
Sensor histidine kinase HpkA; Similar to PID:1575578 GB:AE000512 percent identity: 100.00; identified by sequence similarity; putative.
 
 0.874
TM_0400
Sensor histidine kinase; Similar to PID:1001613 PID:1001628 percent identity: 54.23; identified by sequence similarity; putative.
 
 
  0.831
TM_0853
Sensor histidine kinase; Similar to PID:1575578 GB:AE000512 percent identity: 61.11; identified by sequence similarity; putative.
 
 
  0.830
TM_1258
Sensor histidine kinase, PhoR-related; Similar to GB:M23549 SP:P23545 PID:143331 PID:2293271 GB:AL009126 percent identity: 56.96; identified by sequence similarity; putative.
 
 
  0.830
TM_1358
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.39; identified by sequence similarity; putative.
       0.780
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
     
 0.766
TM_1362
Motility protein PilT; Similar to GB:AE000657 percent identity: 66.67; identified by sequence similarity; putative.
     
 0.750
TM_0842
Response regulator; Similar to PID:1651932 percent identity: 56.68; identified by sequence similarity; putative.
 
 0.721
sigA
RNA polymerase sigma-A factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.702
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.