STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TM_1546Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative. (955 aa)    
Predicted Functional Partners:
TM_1545
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
     
 0.828
priA
Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
 
     0.653
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
   
 0.635
ssb
Single stranded DNA-binding protein, putative; Similar to GB:AE000657 percent identity: 57.14; identified by sequence similarity; putative.
  
 
 
 0.611
wecA
Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.
  
    0.579
TM_1548
Lipopolysaccharide biosynthesis protein; Similar to GP:1773343 percent identity: 61.19; identified by sequence similarity; putative.
       0.575
TM_1547
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.04; identified by sequence similarity; putative.
       0.564
TM_1544
Rod shape-determining protein MreB; Similar to SP:P32444 GB:X62374 PID:49005 percent identity: 74.61; identified by sequence similarity; putative.
  
    0.541
sbcD
Exonuclease, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
  
 0.541
TM_1736
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
  
 0.531
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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