wecA protein (Thermotoga maritima) - STRING interaction network

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wecA

Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily. (291 aa)

Predicted Functional Partners:

TM_1034

0.897

TM_1548

0.880

TM_1547

0.811

TM_0818

0.767

murF

0.714

murD

0.687

murG

0.644

TM_0805

0.613

TM_1546

0.586

TM_1545

0.570

Your Current Organism:

Thermotoga maritima

NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TM_0805	TM_0818	TM_0805	TM_0818	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.	0.714
TM_0805	murD	TM_0805	TM_0234	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.680
TM_0805	murF	TM_0805	TM_0236	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.	0.714
TM_0805	murG	TM_0805	TM_0232	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.	0.612
TM_0805	wecA	TM_0805	TM_1549	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.613
TM_0818	TM_0805	TM_0818	TM_0805	Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.	Lipophilic protein, putative; Similar to PID:1652042 percent identity: 57.62; identified by sequence similarity; putative.	0.714
TM_0818	TM_1034	TM_0818	TM_1034	Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.	UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919 percent identity: 74.59; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	0.449
TM_0818	wecA	TM_0818	TM_1549	Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.	Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.767
TM_1034	TM_0818	TM_1034	TM_0818	UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919 percent identity: 74.59; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	Lipopolysaccharide biosynthesis protein, putative; Similar to GP:2209208 percent identity: 60.39; identified by sequence similarity; putative; Belongs to the glycosyltransferase 26 family.	0.449
TM_1034	TM_1548	TM_1034	TM_1548	UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919 percent identity: 74.59; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	Lipopolysaccharide biosynthesis protein; Similar to GP:1773343 percent identity: 61.19; identified by sequence similarity; putative.	0.411
TM_1034	wecA	TM_1034	TM_1549	UDP-N-acetylglucosamine 2-epimerase; Similar to GB:M87049 SP:P27828 GB:L18799 PID:148189 PID:304919 percent identity: 74.59; identified by sequence similarity; putative; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.	Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.897
TM_1545	TM_1546	TM_1545	TM_1546	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative.	0.824
TM_1545	TM_1547	TM_1545	TM_1547	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.04; identified by sequence similarity; putative.	0.578
TM_1545	TM_1548	TM_1545	TM_1548	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	Lipopolysaccharide biosynthesis protein; Similar to GP:1773343 percent identity: 61.19; identified by sequence similarity; putative.	0.580
TM_1545	wecA	TM_1545	TM_1549	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.570
TM_1546	TM_1545	TM_1546	TM_1545	Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative.	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	0.824
TM_1546	TM_1547	TM_1546	TM_1547	Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative.	Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.04; identified by sequence similarity; putative.	0.565
TM_1546	TM_1548	TM_1546	TM_1548	Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative.	Lipopolysaccharide biosynthesis protein; Similar to GP:1773343 percent identity: 61.19; identified by sequence similarity; putative.	0.576
TM_1546	wecA	TM_1546	TM_1549	Single stranded DNA-specific exonuclease, putative; Similar to GB:AL009126 percent identity: 59.14; identified by sequence similarity; putative.	Methicillin resistance protein; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55), the lipid intermediate involved in the synthesis of various bacterial cell envelope components. The enzyme is highly active when tested with C35- P, instead of its natural C55-P lipid substrate, suggesting that at least a 35-carbon chain is required for the lipid to be a substrate of WecA; Belongs to the glycosyltransferase 4 family. WecA subfamily.	0.586
TM_1547	TM_1545	TM_1547	TM_1545	Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.04; identified by sequence similarity; putative.	Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.	0.578

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