Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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thiIThiamin biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (388 aa)    
Predicted Functional Partners:
TM_1692
Aminotransferase, class V; Similar to SP:P12623 PID:142037 percent identity: 62.03; identified by sequence similarity; putative.
  
 0.997
TM_0980
Hypothetical protein; Identified by sequence similarity; putative.
     
 0.910
TM_0979
Conserved hypothetical protein; Similar to SP:P45530 PID:606277 GB:U00096 PID:1789741 percent identity: 56.94; identified by sequence similarity; putative.
     
 0.907
TM_1512
Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
   
    0.833
TM_1693
1-acyl-sn-glycerol-3-phosphate acetyltransferase, putative; Similar to GB:L32861 PID:520780 GB:AE000783 percent identity: 57.75; identified by sequence similarity; putative; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
       0.815
ttuA
Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2- thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro. Belongs to the TtcA family. TtuA subfamily.
  
 
 0.785
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
  
 
 0.689
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
    0.677
TM_1686
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 58.90; identified by sequence similarity; putative.
  
    0.672
TM_1691
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 53.26; identified by sequence similarity; putative.
       0.671
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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