STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_1822ftsH protease activity modulator HflK; HflC and HflK could encode or regulate a protease. (308 aa)    
Predicted Functional Partners:
TM_1823
ftsH protease activity modulator HflC; HflC and HflK could regulate a protease.
     0.992
ftsH
Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
   
 0.918
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
       0.792
ogg
Conserved hypothetical protein; Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity); Belongs to the type-2 OGG1 family.
       0.792
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
   0.565
TM_1818
Chromate transport protein, putative; Similar to GB:AE000783 percent identity: 61.07; identified by sequence similarity; putative.
       0.544
TM_1819
Chromate transport protein, putative; Similar to PID:687689 percent identity: 55.06; identified by sequence similarity; putative.
       0.544
TM_1346
Processing protease, putative; Similar to SP:Q04805 percent identity: 51.10; identified by sequence similarity; putative; Belongs to the peptidase M16 family.
  
 0.532
TM_0584
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 60.14; identified by sequence similarity; putative.
   
 0.480
TM_1087
Conserved hypothetical protein; Similar to GB:AE000657 percent identity: 70.75; identified by sequence similarity; putative.
   
 0.480
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.