STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_1823ftsH protease activity modulator HflC; HflC and HflK could regulate a protease. (283 aa)    
Predicted Functional Partners:
TM_1822
ftsH protease activity modulator HflK; HflC and HflK could encode or regulate a protease.
     0.992
ftsH
Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
   
 0.815
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
    0.796
ogg
Conserved hypothetical protein; Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity); Belongs to the type-2 OGG1 family.
       0.795
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
   0.582
TM_1346
Processing protease, putative; Similar to SP:Q04805 percent identity: 51.10; identified by sequence similarity; putative; Belongs to the peptidase M16 family.
  
 0.547
TM_1818
Chromate transport protein, putative; Similar to GB:AE000783 percent identity: 61.07; identified by sequence similarity; putative.
       0.544
TM_1819
Chromate transport protein, putative; Similar to PID:687689 percent identity: 55.06; identified by sequence similarity; putative.
       0.544
TM_0865
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 62.69; identified by sequence similarity; putative.
 
 
 0.504
tuf
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
 
 0.435
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.