STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0007Predicted coding region TP0007; Hypothetical protein; identified by Glimmer; putative. (216 aa)    
Predicted Functional Partners:
ptsH
Phosphocarrier protein HPr (ptsH); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
   
 
 0.936
TP_0008
Predicted coding region TP0008; Hypothetical protein; identified by Glimmer; putative.
     
 0.855
Tp75
Tp75 protein; Similar to GB:X61226 PID:48233 percent identity: 100.00; identified by sequence similarity; putative.
     
 0.757
tkt
Transketolase A (tktA); Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
  0.642
prs
Phosphoribosyl pyrophosphate synthetase (prs); Similar to GB:AE000783 percent identity: 44.86; identified by sequence similarity; putative; Belongs to the ribose-phosphate pyrophosphokinase family.
    
 0.641
TP_0223
Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative.
    
  0.619
TP_0413
Phosphoglucomutase; Similar to GB:AE000783 percent identity: 35.60; identified by sequence similarity; putative.
  
 
 0.618
gyrA
DNA gyrase, subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
   0.586
mglB
Methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2); May be involved in the transport of sugars. May have a role in chemotaxis; Belongs to the bacterial solute-binding protein 2 family.
 
 
 0.562
pheT
phenylalanyl-tRNA synthetase beta subunit (pheT); Similar to GP:1785608 percent identity: 39.93; identified by sequence similarity; putative.
  
 
   0.559
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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