STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lon1ATP-dependent protease LA (lon-1); Similar to GB:L42023 SP:P43865 PID:1007316 PID:1221456 PID:1205562 percent identity: 30.50; identified by sequence similarity; putative. (857 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthetase beta subunit (pheT); Similar to GP:1785608 percent identity: 39.93; identified by sequence similarity; putative.
       0.773
lon
ATP-dependent protease LA (lon-2); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
     
 0.592
TP_0017
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 36.16; identified by sequence similarity; putative.
       0.542
tig
Trigger factor (tig); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily.
     
 0.481
tprB
Tpr protein B (tprB); Similar to GP:2196926 percent identity: 37.13; identified by sequence similarity; putative.
       0.449
TP_0012
Predicted coding region TP0012; Hypothetical protein; identified by Glimmer; putative.
       0.449
TP_0013
Predicted coding region TP0013; Hypothetical protein; identified by Glimmer; putative.
       0.449
TP_0014
Predicted coding region TP0014; Hypothetical protein; identified by Glimmer; putative.
       0.449
TP_0018
Transcription elongation factor; Similar to GB:AE000783 percent identity: 33.20; identified by sequence similarity; putative.
       0.435
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
  
    0.401
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.