STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0028Hemolysin, putative; Similar to PID:1653594 percent identity: 26.34; identified by sequence similarity; putative. (453 aa)    
Predicted Functional Partners:
TP_0027
Hemolysin, putative; Similar to GB:AE000783 percent identity: 25.71; identified by sequence similarity; putative.
 
   
0.854
tlyC
Hemolysin (tlyC); Similar to GB:AE000783 percent identity: 51.33; identified by sequence similarity; putative.
  
   
 0.846
TP_0936
Hemolysin, putative; Similar to PID:1653594 percent identity: 27.83; identified by sequence similarity; putative.
  
     0.772
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murA); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
  
    0.568
fliG1
Flagellar motor switch protein (fliG-1); Similar to PID:790528 PID:790935 PID:2105149 percent identity: 28.10; identified by sequence similarity; putative.
       0.458
TP_0140
K+ transport protein (ntpJ); Similar to GP:2635594 percent identity: 37.01; identified by sequence similarity; putative.
     
 0.449
apt
Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
  0.427
TP_0438
Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.423
surE
Survival protein, putative; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.421
TP_0840
Conserved hypothetical integral membrane protein; Similar to GB:AE000782 percent identity: 25.96; identified by sequence similarity; putative.
     
 0.419
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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