STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdBRibonucleoside-diphosphate reductase, subunit beta (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (351 aa)    
Predicted Functional Partners:
nrdA
Ribonucleoside-diphosphate reductase, subunit alpha (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
 
 0.999
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.974
ndk
Nucleoside-diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.966
cmk
Ribosomal protein S1 (rpsA); Similar to SP:P02349 GB:V00342 GB:V00352 GB:X04864 PID:42837 percent identity: 36.77; identified by sequence similarity; putative.
    
 0.965
tmk
Thymidylate kinase (tmk); Similar to GB:L77117 SP:Q57741 PID:1591015 percent identity: 35.14; identified by sequence similarity; putative.
  
 
 0.956
cmk-2
Cytidylate kinase (cmk); Similar to GB:AE000783 percent identity: 42.53; identified by sequence similarity; putative.
     
  0.922
trxA
Thioredoxin (trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
  
 
 0.783
flaB3
Flagellar filament 31 kDa core protein (flaB3); Component of the core of the flagella.
    
   0.761
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 
 0.698
TP_0840
Conserved hypothetical integral membrane protein; Similar to GB:AE000782 percent identity: 25.96; identified by sequence similarity; putative.
     
  0.690
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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