STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0085PTS system, nitrogen regulatory IIA component (ptsN-1); Similar to GB:X16474 SP:P33670 PID:405792 percent identity: 26.35; identified by sequence similarity; putative. (148 aa)    
Predicted Functional Partners:
ptsH
Phosphocarrier protein HPr (ptsH); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
  
 
 0.959
ptsN
PTS system, nitrogen regulatory IIA component (ptsN-2); Similar to GB:D12938 SP:P31222 GB:Z27094 PID:285783 PID:414887 percent identity: 29.86; identified by sequence similarity; putative.
  
  
0.946
fba
Fructose-bisphosphate aldolase (cbbA); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.943
TP_0086
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.86; identified by sequence similarity; putative.
     
 0.659
gph
Phosphoglycolate phosphatase (gph-2); Similar to GB:L42023 SP:P44755 PID:1004013 PID:1222502 PID:1204815 percent identity: 32.55; identified by sequence similarity; putative.
   
  0.655
TP_0084
Predicted coding region TP0084; Hypothetical protein; identified by Glimmer; putative.
       0.511
hprK
HPr kinase (ptsK); Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
  
  
 0.470
rlpA
Rare lipoprotein A, putative; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
   
   0.461
TP_0989
P26; Similar to GB:AE000783 percent identity: 31.90; identified by sequence similarity; putative.
   
   0.414
htrA1
Periplasmic serine protease DO (htrA-1); Similar to GB:L42023 SP:P45129 PID:1007190 PID:1221388 PID:1205500 percent identity: 39.19; identified by sequence similarity; putative.
    
   0.411
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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