STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0100Thioredoxin, putative; Similar to GB:Z23140 SP:P43221 PID:312981 percent identity: 33.05; identified by sequence similarity; putative. (200 aa)    
Predicted Functional Partners:
msrAB
protein-methionine-S-oxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
   
 0.996
ccdA
Cytochrome c biogenesis protein (ccdA); Similar to GP:2313357 percent identity: 36.61; identified by sequence similarity; putative.
 
  
 0.972
ahpC
Alkyl hydroperoxide reductase (ahpC); Similar to PID:1064782 GB:AL009126 percent identity: 48.92; identified by sequence similarity; putative.
  
 0.972
trxB
Thioredoxin reductase (trxB); Similar to GB:AL009126 percent identity: 46.10; identified by sequence similarity; putative.
   
 0.967
TP_0376
Predicted coding region TP0376; Hypothetical protein; identified by Glimmer; putative.
  
 
 0.942
TP_0098
Heat-shock protein, putative; Similar to PID:1046215 SP:P50025 percent identity: 45.69; identified by sequence similarity; putative.
   
 0.918
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.880
nrdA
Ribonucleoside-diphosphate reductase, subunit alpha (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
   
 0.875
ppiB
Peptidyl-prolyl cis-trans isomerase, cyclophilin-binding (cyp); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family.
    
 0.847
TP_0563
Predicted coding region TP0563; Hypothetical protein; identified by Glimmer; putative.
    
 0.843
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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