STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccdACytochrome c biogenesis protein (ccdA); Similar to GP:2313357 percent identity: 36.61; identified by sequence similarity; putative. (264 aa)    
Predicted Functional Partners:
TP_0100
Thioredoxin, putative; Similar to GB:Z23140 SP:P43221 PID:312981 percent identity: 33.05; identified by sequence similarity; putative.
 
  
 0.972
msrAB
protein-methionine-S-oxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  
  
 0.693
trxA
Thioredoxin (trx); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
  
  
 0.550
TP_0678
Predicted coding region TP0678; Hypothetical protein; identified by Glimmer; putative; To B.burgdorferi BB0340.
  
  
 0.516
pyrH
Uridylate kinase (smbA); Catalyzes the reversible phosphorylation of UMP to UDP.
       0.500
TP_0098
Heat-shock protein, putative; Similar to PID:1046215 SP:P50025 percent identity: 45.69; identified by sequence similarity; putative.
       0.497
mgtE
Mg2+ transport protein (mgtE); Acts as a magnesium transporter.
   
   0.438
cheY
Chemotaxis response regulator (cheY); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).
     
 0.431
trxB
Thioredoxin reductase (trxB); Similar to GB:AL009126 percent identity: 46.10; identified by sequence similarity; putative.
  
  
 0.426
ftsZ
Cell division protein (ftsZ); Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
      
 0.424
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.