STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
recQATP-dependent DNA helicase, putative; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 38.81; identified by sequence similarity; putative. (607 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
  
 0.986
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.985
TP_0770
ATP-dependent RNA helicase; Similar to GB:AE000782 percent identity: 50.14; identified by sequence similarity; putative; Belongs to the DEAD box helicase family.
 
  0.981
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.977
sbcD
Exonuclease, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
 
 0.971
TP_0102
Rep helicase, single-stranded DNA-dependent ATPase (rep); Similar to GB:AE000783 percent identity: 45.60; identified by sequence similarity; putative.
 
 0.968
sbcC
Exonuclease (sbcC); SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity); Belongs to the SMC family. SbcC subfamily.
 
 0.965
mutL
DNA mismatch repair protein (mutL); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).
  
 0.920
uvrD
DNA helicase II (uvrD); Similar to GP:2618592 percent identity: 40.96; identified by sequence similarity; putative.
  
 0.906
recB
ATP-dependent nuclease, subunit A, putative; Similar to GB:M63489 SP:P23478 PID:142440 PID:2145362 PID:2226192 percent identity: 29.14; identified by sequence similarity; putative; Belongs to the helicase family. UvrD subfamily.
    
 0.903
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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