STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spoU2rRNA methylase, putative; Similar to GB:D26185 SP:Q06753 GB:L14580 PID:467483 PID:532360 percent identity: 37.93; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (292 aa)    
Predicted Functional Partners:
metG
methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.835
rplC
Ribosomal protein L3 (rplC); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
 
 0.807
rplM
Ribosomal protein L13 (rplM); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.788
rplO
Ribosomal protein L15 (rplO); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
   0.771
rplU
Ribosomal protein L21 (rplU); This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
   0.769
rplX
Ribosomal protein L24 (rplX); One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
  
   0.768
rplK
Ribosomal protein L11 (rplK); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
   0.768
rplQ
Ribosomal protein L17 (rplQ); Similar to GB:AE000783 percent identity: 59.02; identified by sequence similarity; putative.
  
   0.767
TP_0098
Heat-shock protein, putative; Similar to PID:1046215 SP:P50025 percent identity: 45.69; identified by sequence similarity; putative.
   
   0.764
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity).
   
   0.764
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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