STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdxKPhosphomethypyrimidine kinase (thiD); Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity); Belongs to the ThiD family. (269 aa)    
Predicted Functional Partners:
TP_0518
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 32.48; identified by sequence similarity; putative.
    
 0.791
truA
Pseudouridylate synthase (hisT); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.750
TP_0107
licC protein (licC); Similar to GB:L42023 PID:1007733 PID:1221685 PID:1205774 PID:1574381 percent identity: 29.03; identified by sequence similarity; putative.
     
 0.635
TP_0770
ATP-dependent RNA helicase; Similar to GB:AE000782 percent identity: 50.14; identified by sequence similarity; putative; Belongs to the DEAD box helicase family.
 
 
    0.614
TP_0731
Conserved hypothetical protein; Similar to PID:1652491 percent identity: 36.19; identified by sequence similarity; putative; Belongs to the Nudix hydrolase family.
     
 0.567
nrdA
Ribonucleoside-diphosphate reductase, subunit alpha (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
  
  
 0.558
uvrB
Excinuclease ABC, subunit B (uvrB); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dis [...]
       0.523
TP_0502
Predicted coding region TP0502; Hypothetical protein; identified by Glimmer; putative.
    
  0.512
TP_0835
Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative.
    
  0.512
clpB
ATP-dependent Clp protease subunit B (clpB); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA [...]
   
 
  0.477
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.