STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metNAmino acid ABC transporter, ATP-binding protein (abc); Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (269 aa)    
Predicted Functional Partners:
metI
Amino acid ABC transporter, permease protein (yaeE); Similar to GP:2314762 percent identity: 44.55; identified by sequence similarity; putative.
 
 0.999
tpn32
Lipoprotein (tpn32); Similar to GP:2108234 percent identity: 100.00; identified by sequence similarity; putative.
 
 0.999
troR
Cation-activated repressor protein (troR); Similar to GP:1777937 percent identity: 100.00; identified by sequence similarity; putative.
    
   0.927
TP_0963
Conserved hypothetical integral membrane protein; Similar to GB:AL009126 percent identity: 31.84; identified by sequence similarity; putative.
 
      0.794
metK
S-adenosylmethionine synthetase (metK); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.771
TP_0962
Conserved hypothetical integral membrane protein; Similar to GB:AL009126 percent identity: 28.89; identified by sequence similarity; putative.
 
      0.704
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
    
  0.577
lolD
ABC transporter, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
  
  
 
0.561
TP_0223
Aspartate aminotransferase (tpaaT); Similar to GP:2104501 percent identity: 99.77; identified by sequence similarity; putative.
  
   0.543
TP_0121
Conserved hypothetical protein; Similar to GB:L42023 SP:P44641 PID:1003549 PID:1222253 PID:1204581 percent identity: 30.37; identified by sequence similarity; putative; Belongs to the radical SAM superfamily. KamA family.
       0.533
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.