Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rnfDConserved hypothetical integral membrane protein; Similar to GP:1787917 percent identity: 29.71; identified by sequence similarity; putative. (339 aa)    
Predicted Functional Partners:
rnfC
Nitrogen fixation protein (rnfC); Similar to GB:X72888 GB:X79064 PID:435525 PID:483572 PID:1905810 percent identity: 27.00; identified by sequence similarity; putative.
  
 
 0.998
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
   
 
 0.958
TP_0147
Alpha-amylase 1, putative; Similar to SP:P09961 PID:2689 percent identity: 27.92; identified by sequence similarity; putative.
     
 0.881
TP_0149
Predicted coding region TP0149; Hypothetical protein; identified by Glimmer; putative.
     
 0.870
TP_0150
Predicted coding region TP0150; Hypothetical protein; identified by Glimmer; putative.
     
 0.815
TP_0148
Predicted coding region TP0148; Hypothetical protein; identified by Glimmer; putative.
     
 0.808
TP_0153
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 37.67; identified by sequence similarity; putative.
     
 0.793
TP_0572
Predicted coding region TP0572; Hypothetical protein; identified by Glimmer; putative.
     
 0.698
apbE
Conserved hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Displays FAD pyrophosphatase activity in vitro, hydrolyzing FAD into FMN and AMP.
  
  
 0.695
mgtE
Mg2+ transport protein (mgtE); Acts as a magnesium transporter.
    
 
 0.472
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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