STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0156Conserved hypothetical protein; Similar to GB:L42023 SP:P44679 PID:1003656 PID:1222312 PID:1204635 percent identity: 31.50; identified by sequence similarity; putative. (134 aa)    
Predicted Functional Partners:
acpP
Acyl carrier protein (acpP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 0.887
TP_0158
Conserved hypothetical protein; Similar to SP:P40025 PID:603270 percent identity: 24.62; identified by sequence similarity; putative.
       0.787
plsC
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 33.85; identified by sequence similarity; putative.
       0.781
TP_0159
Predicted coding region TP0159; Hypothetical protein; identified by Glimmer; putative.
       0.773
proS
prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...]
       0.691
acpS
Holo-acyl-carrier protein synthase (acpS); Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
    
  0.691
coxL
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 26.11; identified by sequence similarity; putative.
     
  0.690
coxS
Quinoline 2-oxidoreductase; Similar to GP:1644310 percent identity: 30.34; identified by sequence similarity; putative.
     
  0.690
coxM
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 26.50; identified by sequence similarity; putative.
     
  0.690
secA
Preprotein translocase subunit (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family.
   
   0.593
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.