STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0158Conserved hypothetical protein; Similar to SP:P40025 PID:603270 percent identity: 24.62; identified by sequence similarity; putative. (228 aa)    
Predicted Functional Partners:
plsC
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 33.85; identified by sequence similarity; putative.
       0.795
TP_0156
Conserved hypothetical protein; Similar to GB:L42023 SP:P44679 PID:1003656 PID:1222312 PID:1204635 percent identity: 31.50; identified by sequence similarity; putative.
  
    0.789
TP_0159
Predicted coding region TP0159; Hypothetical protein; identified by Glimmer; putative.
       0.773
proS
prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...]
       0.635
TP_0731
Conserved hypothetical protein; Similar to PID:1652491 percent identity: 36.19; identified by sequence similarity; putative; Belongs to the Nudix hydrolase family.
  
 
 0.617
TP_0290
Conserved hypothetical protein; Similar to GP:1418999 percent identity: 27.07; identified by sequence similarity; putative.
    
 0.601
nadE
NH(3)-dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.
  
  
 0.598
TP_0551
Phosphatase; Similar to GB:L25421 PID:409159 percent identity: 32.50; identified by sequence similarity; putative.
 
  
 0.595
spsE
Spore coat polysaccharide biosynthesis protein (spsE); Similar to GB:X73124 SP:P39625 PID:413991 GB:AL009126 percent identity: 27.64; identified by sequence similarity; putative.
  
 
 0.582
TP_0147
Alpha-amylase 1, putative; Similar to SP:P09961 PID:2689 percent identity: 27.92; identified by sequence similarity; putative.
 
  
  0.580
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.