STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0158Conserved hypothetical protein; Similar to SP:P40025 PID:603270 percent identity: 24.62; identified by sequence similarity; putative. (228 aa)    
Predicted Functional Partners:
TP_0156
Conserved hypothetical protein; Similar to GB:L42023 SP:P44679 PID:1003656 PID:1222312 PID:1204635 percent identity: 31.50; identified by sequence similarity; putative.
       0.787
plsC
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 33.85; identified by sequence similarity; putative.
       0.787
TP_0159
Predicted coding region TP0159; Hypothetical protein; identified by Glimmer; putative.
       0.773
proS
prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...]
       0.631
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.590
TP_0551
Phosphatase; Similar to GB:L25421 PID:409159 percent identity: 32.50; identified by sequence similarity; putative.
 
 
  0.587
TP_0290
Conserved hypothetical protein; Similar to GP:1418999 percent identity: 27.07; identified by sequence similarity; putative.
    
 0.558
gph
Phosphoglycolate phosphatase (gph-2); Similar to GB:L42023 SP:P44755 PID:1004013 PID:1222502 PID:1204815 percent identity: 32.55; identified by sequence similarity; putative.
    
 0.557
TP_0147
Alpha-amylase 1, putative; Similar to SP:P09961 PID:2689 percent identity: 27.92; identified by sequence similarity; putative.
 
  
  0.550
TP_0623
Membrane-bound lytic murein transglycosylase D (dniR); Similar to SP:P23931 GB:X60739 PID:1208972 PID:581068 GB:U00096 percent identity: 32.28; identified by sequence similarity; putative.
    
 0.550
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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