STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tpp15Lipoprotein, 15 kDa (tpp15); Similar to GB:M30941 SP:P16055 PID:155073 PID:1777940 percent identity: 97.12; identified by sequence similarity; putative. (142 aa)    
Predicted Functional Partners:
apbE
Conserved hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Displays FAD pyrophosphatase activity in vitro, hydrolyzing FAD into FMN and AMP.
 
   
 0.839
TP_0348
Predicted coding region TP0348; Hypothetical protein; identified by Glimmer; putative.
 
     0.662
tpf1
Bacterioferrin (TpF1); May play an important structural role in the outer membrane; Belongs to the Dps family.
    
 
 0.538
tpd
Membrane antigen, pathogen-specific (tpd); This antigen is a pathogen-specific membrane immunogen; Belongs to the UPF0423 family.
   
 
 0.530
TP_0169
Predicted coding region TP0169; Hypothetical protein; identified by Glimmer; putative.
       0.526
mtnN
Pfs protein (pfs); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
       0.526
tpp17
Lipoprotein, 17 kDa (tpp17); Similar to GB:M74825 SP:P29722 PID:155048 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.499
TP_1032
Predicted coding region TP1032; Hypothetical protein; identified by Glimmer; putative.
   
   0.498
TP_0574
Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...]
      
 0.471
rnfC
Nitrogen fixation protein (rnfC); Similar to GB:X72888 GB:X79064 PID:435525 PID:483572 PID:1905810 percent identity: 27.00; identified by sequence similarity; putative.
  
   
 0.459
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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