STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0183Predicted coding region TP0183; Hypothetical protein; identified by Glimmer; putative. (281 aa)    
Predicted Functional Partners:
dnaA
Chromosomal replication initiator protein (dnaA); Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
    
 
 0.807
smpB
Small protein (smpB); Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
       0.789
sbcD
Exonuclease, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.
    
 
 0.703
TP_0380
DNA repair helicase, putative; Similar to GB:Z47047 SP:Q00578 PID:172327 PID:172724 PID:557780 percent identity: 32.92; identified by sequence similarity; putative.
    
 
 0.673
lepB1
Signal peptidase I (sip); Similar to GB:AL009126 percent identity: 34.93; identified by sequence similarity; putative; Belongs to the peptidase S26 family.
       0.525
TP_0004
Predicted coding region TP0004; Hypothetical protein; identified by Glimmer; putative.
      
 0.509
TP_0050
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 41.88; identified by sequence similarity; putative.
      
 0.491
hup
DNA-binding protein II; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
      
 0.491
hrpA
ATP-dependent helicase (hrpA); Similar to GB:AE000783 percent identity: 49.18; identified by sequence similarity; putative.
      
 0.491
dnaG
DNA primase (dnaG); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
      
 0.487
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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