STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0231Conserved hypothetical protein; Similar to PID:882688 GB:U00096 SP:Q46918 PID:1789155 PID:882686 percent identity: 36.22; identified by sequence similarity; putative. (216 aa)    
Predicted Functional Partners:
spoU1
Conserved hypothetical protein; Similar to GB:U14003 SP:P39290 PID:537021 GB:U00096 PID:1790623 percent identity: 31.43; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
 
   0.943
spoU2
rRNA methylase, putative; Similar to GB:D26185 SP:Q06753 GB:L14580 PID:467483 PID:532360 percent identity: 37.93; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
 
   0.942
mnmE
Thiophene and furan oxidation protein (thdF); Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
   
 
 0.940
rplK
Ribosomal protein L11 (rplK); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
   0.938
TP_0098
Heat-shock protein, putative; Similar to PID:1046215 SP:P50025 percent identity: 45.69; identified by sequence similarity; putative.
 
 
   0.937
rplQ
Ribosomal protein L17 (rplQ); Similar to GB:AE000783 percent identity: 59.02; identified by sequence similarity; putative.
   
   0.934
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity).
  
 
 0.934
rplU
Ribosomal protein L21 (rplU); This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
   0.934
rplM
Ribosomal protein L13 (rplM); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
   0.932
rplN
Ribosomal protein L14 (rplN); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
   
   0.931
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.