STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
flaAFlagellar filament outer layer protein (flaA-1); Component of the outer layer of the flagella. (350 aa)    
Predicted Functional Partners:
flaB3
Flagellar filament 31 kDa core protein (flaB3); Component of the core of the flagella.
      
 0.858
flaB1
Flagellar filament 34.5 kDa core protein (flaB1); Component of the core of the flagella.
      
 0.779
TP_0248
Predicted coding region TP0248; Hypothetical protein; identified by Glimmer; putative.
     
 0.698
TP_0250
Predicted coding region TP0250; Hypothetical protein; identified by Glimmer; putative.
       0.613
flaB2
Flagellar filament 33 kDa core protein (flaB2); Component of the core of the flagella.
      
 0.611
flgE
Flagellar hook protein (flgE); Similar to GP:2196893 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.603
amiC
N-acetylmuramoyl-L-alanine amidase (amiA); Similar to SP:P36548 GB:X75413 PID:453968 GB:U00096 PID:1788776 percent identity: 30.74; identified by sequence similarity; putative.
       0.580
lepB2
Signal peptidase I, putative; Similar to GB:X75604 SP:P42668 PID:580781 percent identity: 42.19; identified by sequence similarity; putative; Belongs to the peptidase S26 family.
      
 0.469
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
      
 0.433
TP_0574
Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...]
      
 0.433
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.