STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0312Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 28.69; identified by sequence similarity; putative. (337 aa)    
Predicted Functional Partners:
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.587
TP_0309
Amino acid ABC transporter, periplasmic binding protein; Similar to SP:P42199 PID:666981 GB:AL009126 percent identity: 25.87; identified by sequence similarity; putative.
       0.569
tprE
Tpr protein E (tprE); Similar to GP:2196926 percent identity: 70.32; identified by sequence similarity; putative.
       0.538
ssb2
Predicted coding region TP0310; Hypothetical protein; identified by Glimmer; putative.
       0.518
ispDF
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
     
 0.499
TP_0790
Antibiotic transport protein, putative; Similar to GB:U00010 PID:466786 percent identity: 24.60; identified by sequence similarity; putative.
  
     0.483
TP_0308
Amino acid ABC transporter, periplasmic binding protein (hisJ); Similar to GB:J01805 SP:P02910 GB:V01372 GB:V01373 GB:X52093 percent identity: 24.37; identified by sequence similarity; putative.
       0.465
TP_0307
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 21.80; identified by sequence similarity; putative.
       0.402
pyrG
CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
       0.401
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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