STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmk-2Cytidylate kinase (cmk); Similar to GB:AE000783 percent identity: 42.53; identified by sequence similarity; putative. (186 aa)    
Predicted Functional Partners:
ndk
Nucleoside-diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.961
nrdA
Ribonucleoside-diphosphate reductase, subunit alpha (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
    
  0.925
nrdB
Ribonucleoside-diphosphate reductase, subunit beta (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
     
  0.922
dctD
Deoxycytidylate deaminase, putative; Similar to GB:AE000782 percent identity: 47.95; identified by sequence similarity; putative.
     
  0.922
surE
Survival protein, putative; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.922
TP_0104
5'-nucleotidase (ushA); Similar to GB:L42023 SP:P44569 PID:1003311 PID:1222124 PID:1204463 percent identity: 50.63; identified by sequence similarity; putative.
     
  0.907
rplV
Ribosomal protein L22 (rplV); This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
  
    0.836
rplN
Ribosomal protein L14 (rplN); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
    0.833
rplX
Ribosomal protein L24 (rplX); One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
  
    0.833
rpsB
Ribosomal protein S2 (rpsB); Similar to GB:AE000783 percent identity: 58.75; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family.
 
    0.829
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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