STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0348Predicted coding region TP0348; Hypothetical protein; identified by Glimmer; putative. (469 aa)    
Predicted Functional Partners:
TP_1032
Predicted coding region TP1032; Hypothetical protein; identified by Glimmer; putative.
 
    0.945
slyD
Peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction; Belongs to the FKBP-type PPI [...]
       0.789
TP_0683
Octaprenyl-diphosphate synthase; Similar to GP:2072008 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family.
  
 
 0.720
apbE
Conserved hypothetical protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Displays FAD pyrophosphatase activity in vitro, hydrolyzing FAD into FMN and AMP.
 
   
 0.710
tpp15
Lipoprotein, 15 kDa (tpp15); Similar to GB:M30941 SP:P16055 PID:155073 PID:1777940 percent identity: 97.12; identified by sequence similarity; putative.
 
     0.674
cbiO
Cobalt ABC transporter, ATP-binding protein; Similar to GB:L77117 PID:1591732 percent identity: 37.91; identified by sequence similarity; putative.
    
  0.521
rnfC
Nitrogen fixation protein (rnfC); Similar to GB:X72888 GB:X79064 PID:435525 PID:483572 PID:1905810 percent identity: 27.00; identified by sequence similarity; putative.
 
     0.504
TP_1029
Predicted coding region TP1029; Hypothetical protein; identified by Glimmer; putative.
  
     0.490
proA
Glutamate-5-semialdehyde dehydrogenase (proA); Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
       0.485
proB
Glutamate 5-kinase (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
       0.484
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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