STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0443Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 28.10; identified by sequence similarity; putative. (284 aa)    
Predicted Functional Partners:
fliG2
Flagellar motor switch protein (fliG-2); FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
   
 
 0.838
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
       0.837
recN
DNA repair protein (recN); May be involved in recombinational repair of damaged DNA.
       0.837
wecE
Spore coat polysaccharide biosynthesis protein, putative; Similar to PID:1653135 percent identity: 23.08; identified by sequence similarity; putative; Belongs to the DegT/DnrJ/EryC1 family.
       0.835
TP_0444
Conserved hypothetical protein; Similar to PID:887815 GB:U00096 PID:1789228 percent identity: 30.14; identified by sequence similarity; putative.
       0.773
cheW
Purine-binding chemotaxis protein (cheW-2); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
       0.661
TP_0648
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 22.78; identified by sequence similarity; putative.
    
 
 0.618
fliE
Flagellar hook-basal body complex protein (fliE); Similar to GP:2105147 percent identity: 58.12; identified by sequence similarity; putative.
   
 
 0.564
TP_0445
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ); Similar to GB:AE000783 percent identity: 31.82; identified by sequence similarity; putative.
       0.487
TP_0359
Predicted coding region TP0359; Hypothetical protein; identified by Glimmer; putative.
   
   0.460
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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