STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP_0444Conserved hypothetical protein; Similar to PID:887815 GB:U00096 PID:1789228 percent identity: 30.14; identified by sequence similarity; putative. (342 aa)    
Predicted Functional Partners:
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
       0.779
recN
DNA repair protein (recN); May be involved in recombinational repair of damaged DNA.
       0.778
wecE
Spore coat polysaccharide biosynthesis protein, putative; Similar to PID:1653135 percent identity: 23.08; identified by sequence similarity; putative; Belongs to the DegT/DnrJ/EryC1 family.
       0.773
TP_0443
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 28.10; identified by sequence similarity; putative.
       0.773
cheW
Purine-binding chemotaxis protein (cheW-2); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.
       0.539
TP_0702
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 31.72; identified by sequence similarity; putative.
  
   
 0.529
TP_0445
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ); Similar to GB:AE000783 percent identity: 31.82; identified by sequence similarity; putative.
       0.489
ispG
gcpE protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
    0.416
TP_0447
Predicted coding region TP0447; Hypothetical protein; identified by Glimmer; putative.
       0.415
TP_0877
Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 31.09; identified by sequence similarity; putative.
      
 0.406
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.