STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0447Predicted coding region TP0447; Hypothetical protein; identified by Glimmer; putative. (374 aa)    
Predicted Functional Partners:
ispG
gcpE protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
       0.815
TP_0445
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ); Similar to GB:AE000783 percent identity: 31.82; identified by sequence similarity; putative.
       0.636
TP_0449
Predicted coding region TP0449; Hypothetical protein; identified by Glimmer; putative.
       0.605
upp
Uracil phosphoribosyltransferase, putative; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
       0.596
TP_0468
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 28.43; identified by sequence similarity; putative.
  
 
  0.540
ndk
Nucleoside-diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
  0.491
mcp1
Methyl-accepting chemotaxis protein (mcp1); Similar to GP:1354776 percent identity: 100.00; identified by sequence similarity; putative.
    
  0.468
mcp2
Methyl-accepting chemotaxis protein (mcp2-1); Similar to GP:2367665 percent identity: 99.77; identified by sequence similarity; putative.
    
  0.468
TP_0639
Methyl-accepting chemotaxis protein (mcp2-2); Similar to GP:2367665 percent identity: 33.84; identified by sequence similarity; putative.
    
  0.468
mcp4
Methyl-accepting chemotaxis protein (mcp2-3); Similar to GP:2352917 percent identity: 29.09; identified by sequence similarity; putative.
    
  0.468
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.