STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TP_0449Predicted coding region TP0449; Hypothetical protein; identified by Glimmer; putative. (196 aa)    
Predicted Functional Partners:
upp
Uracil phosphoribosyltransferase, putative; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
       0.773
cheW1
Purine-binding chemotaxis protein (cheW-1); Similar to GP:1765974 percent identity: 99.78; identified by sequence similarity; putative.
    
  0.648
ispG
gcpE protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
  
    0.629
TP_0447
Predicted coding region TP0447; Hypothetical protein; identified by Glimmer; putative.
       0.603
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
   
   0.582
TP_0445
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (thiJ); Similar to GB:AE000783 percent identity: 31.82; identified by sequence similarity; putative.
       0.497
fusB
Translation elongation factor G (fusA-1); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor G [...]
       0.487
TP_0225
Leucine-rich repeat protein TpLRR; Similar to GP:2104502 percent identity: 100.00; identified by sequence similarity; putative.
   
   0.434
prc
Carboxyl-terminal protease (ctp); Similar to PID:559865 PID:1657989 percent identity: 37.36; identified by sequence similarity; putative; Belongs to the peptidase S41A family.
   
   0.434
TP_0989
P26; Similar to GB:AE000783 percent identity: 31.90; identified by sequence similarity; putative.
   
   0.434
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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