STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0453Predicted coding region TP0453; Might be involved in ligand transport, alters membrane permeability at acidic pH (4.0 to 5.5). Incubation of the non-lipidated form with lipid vesicles increases their permeability. (287 aa)    
Predicted Functional Partners:
ileS
isoleucyl-tRNA synthetase (ileS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
       0.789
prc
Carboxyl-terminal protease (ctp); Similar to PID:559865 PID:1657989 percent identity: 37.36; identified by sequence similarity; putative; Belongs to the peptidase S41A family.
      
 0.546
glpQ
Glycerophosphoryldiester phosphodiesterase (glpQ); Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
      
 0.509
tmpA
Membrane protein (tmpA); Similar to SP:P07643 PID:155069 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.509
macA
Membrane fusion protein, putative; Similar to GB:L42023 PID:1005989 PID:1220998 PID:1205141 SP:Q57500 percent identity: 25.88; identified by sequence similarity; putative.
      
 0.450
TP_0574
Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...]
      
 0.432
TP_0751
Predicted coding region TP0751; Hypothetical protein; identified by Glimmer; putative.
      
 0.432
TP_0451
Predicted coding region TP0451; Hypothetical protein; identified by Glimmer; putative.
       0.426
tp92
Outer membrane protein; Might be part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane; Belongs to the BamA family.
      
 0.406
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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