STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0519Response regulatory protein (atoC); Similar to GB:AE000783 percent identity: 54.34; identified by sequence similarity; putative. (458 aa)    
Predicted Functional Partners:
fliY
Flagellar motor switch protein (fliY); FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
 
 0.998
cheW1
Purine-binding chemotaxis protein (cheW-1); Similar to GP:1765974 percent identity: 99.78; identified by sequence similarity; putative.
  
 
 0.995
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
    
 0.987
fleN1
ATP-binding protein (ylxH-1); Similar to PID:1216382 PID:1216385 percent identity: 100.00; identified by sequence similarity; putative.
  
 0.974
fleN2
ATP-binding protein (ylxH-2); Similar to GB:AE000783 percent identity: 41.64; identified by sequence similarity; putative.
  
 0.974
cheA
Chemotaxis histidine kinase (cheA); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
  
 0.972
TP_0485
Adenylate cyclase; Similar to GP:1754638 percent identity: 40.99; identified by sequence similarity; putative.
   
 0.969
fliM
Flagellar motor switch protein (fliM); FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
  
 
 0.964
rpoN
RNA polymerase sigma-54 factor (rpoN); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.950
fliH
Flagellar assembly protein (fliH); Needed for flagellar regrowth and assembly; Belongs to the FliH family.
  
 
 0.946
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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