STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0545Methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1); Similar to SP:P23925 GB:X59389 PID:40473 percent identity: 37.27; identified by sequence similarity; putative. (354 aa)    
Predicted Functional Partners:
mglA
Methylgalactoside ABC transporter, ATP binding protein (mglA); Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
 
 0.996
mglC
Methylgalactoside ABC transporter, permease protein (mglC); Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane (By similarity).
 
 
  0.976
cheW1
Purine-binding chemotaxis protein (cheW-1); Similar to GP:1765974 percent identity: 99.78; identified by sequence similarity; putative.
    
 0.945
TP_0544
Predicted coding region TP0544; Hypothetical protein; identified by Glimmer; putative.
  
    0.703
ruvA
Holliday junction DNA helicase (ruvA); The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
       0.585
TP_0546
Periplasmic serine protease, putative; Similar to GB:L20127 PID:310329 percent identity: 37.30; identified by sequence similarity; putative.
       0.550
ispH
Penicillin tolerance protein (lytB); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
       0.550
TP_0519
Response regulatory protein (atoC); Similar to GB:AE000783 percent identity: 54.34; identified by sequence similarity; putative.
    
 0.539
proA
Glutamate-5-semialdehyde dehydrogenase (proA); Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
    
   0.530
cheA
Chemotaxis histidine kinase (cheA); Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
     
 0.509
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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