STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0546Periplasmic serine protease, putative; Similar to GB:L20127 PID:310329 percent identity: 37.30; identified by sequence similarity; putative. (666 aa)    
Predicted Functional Partners:
htrA2
Periplasmic serine protease DO (htrA-2); Similar to GB:AE000783 percent identity: 41.83; identified by sequence similarity; putative.
  
  
 
0.945
ispH
Penicillin tolerance protein (lytB); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
     
 0.796
rplY
General stress protein (ctc); This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
   0.635
TP_0261
Catabolite gene activator, putative; Similar to PID:1653345 percent identity: 30.99; identified by sequence similarity; putative.
   
 0.577
rplI
Ribosomal protein L9 (rplI); Binds to the 23S rRNA.
 
 
   0.574
TP_0468
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 28.43; identified by sequence similarity; putative.
   
 0.563
dnaK
Heat shock protein 70 (dnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.561
TP_0545
Methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1); Similar to SP:P23925 GB:X59389 PID:40473 percent identity: 37.27; identified by sequence similarity; putative.
   
   0.559
TP_0835
Ankyrin, putative; Similar to GB:X56958 SP:Q01485 PID:29491 percent identity: 30.66; identified by sequence similarity; putative.
  
  0.555
fklB
Peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB); Similar to GB:U14003 SP:P39311 PID:537048 GB:U00096 PID:1790652 percent identity: 43.46; identified by sequence similarity; putative.
   
 
 0.546
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.