STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0548Predicted coding region TP0548; Hypothetical protein; identified by Glimmer; putative; Belongs to the UPF0164 family. (434 aa)    
Predicted Functional Partners:
ispH
Penicillin tolerance protein (lytB); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
     
 0.647
TP_0136
Predicted coding region TP0136; Hypothetical protein; identified by Glimmer; putative.
      
 0.613
tprE
Tpr protein E (tprE); Similar to GP:2196926 percent identity: 70.32; identified by sequence similarity; putative.
      
 0.613
mrcA
Penicillin-binding protein (pbp-2); Similar to GB:AE000783 percent identity: 40.76; identified by sequence similarity; putative.
      
 0.613
clpA1
ATPase (clpC); Similar to GB:D26185 SP:P37571 GB:U02604 GB:X75930 PID:442360 percent identity: 44.35; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family.
     
 0.592
tprG
Tpr protein G (tprG); Similar to GP:2196926 percent identity: 85.22; identified by sequence similarity; putative.
      
 0.580
tprJ
Tpr protein J (tprJ); Similar to GP:2196926 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.560
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
      
 0.542
mcp2
Methyl-accepting chemotaxis protein (mcp2-1); Similar to GP:2367665 percent identity: 99.77; identified by sequence similarity; putative.
      
 0.529
TP_0546
Periplasmic serine protease, putative; Similar to GB:L20127 PID:310329 percent identity: 37.30; identified by sequence similarity; putative.
       0.527
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.