STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thiIConserved hypothetical protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (401 aa)    
Predicted Functional Partners:
nifS
Nitrogen fixation protein (nifS-2); Similar to GB:M86823 SP:Q01179 GB:U22347 PID:151968 percent identity: 38.19; identified by sequence similarity; putative.
 
 0.994
TP_0404
Predicted coding region TP0404; Hypothetical protein; identified by Glimmer; putative.
    
  0.690
nicO
Conserved hypothetical integral membrane protein; Similar to GB:L42023 SP:P44136 PID:1007168 PID:1221377 PID:1205489 percent identity: 24.48; identified by sequence similarity; putative; Belongs to the NiCoT transporter (TC 2.A.52) family.
       0.588
dxs
Transketolase B (tktB); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
     
 0.573
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family.
     
 0.546
metG
methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.528
TP_0557
Conserved hypothetical protein; Similar to GB:M55917 SP:P22041 PID:152899 percent identity: 30.71; identified by sequence similarity; putative.
       0.518
spoU1
Conserved hypothetical protein; Similar to GB:U14003 SP:P39290 PID:537021 GB:U00096 PID:1790623 percent identity: 31.43; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
  
 
 0.512
argS
arginyl-tRNA synthetase (argS); Similar to GB:AE000783 percent identity: 43.07; identified by sequence similarity; putative.
  
  
 0.505
trmB
Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
   
  
 0.497
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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