STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
eda4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase (eda); Similar to GB:L42023 PID:1004194 PID:1221953 PID:1204305 SP:P44480 percent identity: 43.63; identified by sequence similarity; putative; Belongs to the KHG/KDPG aldolase family. (210 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase (gpi); Similar to GB:AE000783 percent identity: 46.56; identified by sequence similarity; putative.
  
 
 0.966
gap
Glyceraldehyde 3-phosphate dehydrogenase (gap); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
  
 
 0.955
tpiA
Triosephosphate isomerase (tpi); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
     
 0.953
fba
Fructose-bisphosphate aldolase (cbbA); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
    
 0.940
eno
Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.937
ppdK
Pyruvate, phosphate dikinase; Catalyzes the reversible phosphorylation of pyruvate and phosphate; Belongs to the PEP-utilizing enzyme family.
     
 0.936
gpmA
Phosphoglycerate mutase (pgm); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
     
 0.935
TP_0939
Pyruvate oxidoreductase; Similar to PID:1001780 SP:P52965 PID:1006618 percent identity: 58.44; identified by sequence similarity; putative.
    
 0.935
TP_0413
Phosphoglucomutase; Similar to GB:AE000783 percent identity: 35.60; identified by sequence similarity; putative.
     
 0.925
TP_0642
Phosphomannomutase (manB); Similar to GB:M34393 SP:P18159 PID:142994 PID:2226139 GB:AL009126 percent identity: 41.55; identified by sequence similarity; putative.
     
 0.925
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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