STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TP_0574Carboxypeptidase, 47 kDa; A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, no [...] (434 aa)    
Predicted Functional Partners:
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
      
 0.613
pbp1
Penicillin-binding protein (pbp-1); Similar to GB:AE000783 percent identity: 37.14; identified by sequence similarity; putative.
      
 0.613
pbp2
Penicillin-binding protein (pbp-3); Similar to GB:AE000783 percent identity: 30.81; identified by sequence similarity; putative.
      
 0.613
tmpA
Membrane protein (tmpA); Similar to SP:P07643 PID:155069 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.613
TP_0572
Predicted coding region TP0572; Hypothetical protein; identified by Glimmer; putative.
       0.608
TP_0076
Sugar ABC transporter, permease protein (y4oR); Similar to SP:P55603 PID:2182562 percent identity: 35.38; identified by sequence similarity; putative.
  
    0.547
tpp17
Lipoprotein, 17 kDa (tpp17); Similar to GB:M74825 SP:P29722 PID:155048 percent identity: 100.00; identified by sequence similarity; putative.
      
 0.509
TP_0571
Tp70 protein; Similar to GB:X61227 PID:48231 percent identity: 96.67; identified by sequence similarity; putative.
       0.491
tpp15
Lipoprotein, 15 kDa (tpp15); Similar to GB:M30941 SP:P16055 PID:155073 PID:1777940 percent identity: 97.12; identified by sequence similarity; putative.
      
 0.457
TP_0548
Predicted coding region TP0548; Hypothetical protein; identified by Glimmer; putative; Belongs to the UPF0164 family.
      
 0.450
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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