STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcnB2Polynucleotide adenylyltransferase (pcnB); Similar to SP:P13685 GB:D26562 GB:M20574 GB:S48039 PID:147117 percent identity: 41.91; identified by sequence similarity; putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (370 aa)    
Predicted Functional Partners:
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family.
    
 0.786
metG
methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
 
 
 0.713
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
       0.706
pcnB1
Polynucleotide adenylyltransferase (pcnA); Similar to GB:AE000783 percent identity: 35.36; identified by sequence similarity; putative.
  
  
 
0.688
pnp
Polyribonucleotide nucleotidyltransferase (pnp); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.673
TP_0594
Predicted coding region TP0594; Hypothetical protein; identified by Glimmer; putative.
       0.632
TP_0805
Exoribonuclease II (rnb); Similar to PID:1652280 percent identity: 30.83; identified by sequence similarity; putative.
  
 
 0.596
TP_0597
Predicted coding region TP0597; Hypothetical protein; identified by Glimmer; putative.
  
   0.583
TP_0598
Predicted coding region TP0598; Hypothetical protein; identified by Glimmer; putative.
  
   0.583
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.551
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.