STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP_0599Predicted coding region TP0599; Hypothetical protein; identified by Glimmer; putative. (218 aa)    
Predicted Functional Partners:
TP_0600
Zinc protease, putative; Similar to GB:L42023 SP:P44936 PID:1006037 PID:1221023 PID:1205165 percent identity: 32.94; identified by sequence similarity; putative; Belongs to the peptidase M50B family.
       0.827
dxr
Conserved hypothetical protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
       0.827
uppS
Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
       0.826
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
       0.826
cdsA
Phosphatidate cytidylyltransferase (cdsA); Similar to GB:AE000783 percent identity: 32.47; identified by sequence similarity; putative.
       0.773
TP_0597
Predicted coding region TP0597; Hypothetical protein; identified by Glimmer; putative.
       0.695
TP_0598
Predicted coding region TP0598; Hypothetical protein; identified by Glimmer; putative.
       0.695
tsf
Translation elongation factor TS (tsf); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family.
       0.561
pcnB2
Polynucleotide adenylyltransferase (pcnB); Similar to SP:P13685 GB:D26562 GB:M20574 GB:S48039 PID:147117 percent identity: 41.91; identified by sequence similarity; putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
       0.449
adk
Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
       0.415
Your Current Organism:
Treponema pallidum
NCBI taxonomy Id: 243276
Other names: T. pallidum subsp. pallidum str. Nichols, Treponema pallidum Nichols, Treponema pallidum subsp. pallidum str. Nichols
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